A Clinical Perspective from Two Decades of LDN Practice Yoon Hang Kim, MD, MPH, FAAMA Direct Integrative Care & Functional Medicine via Telemedicine Serving IA, IL, MO, GA, FL, TX www.directintegrativecare.com Introduction Long COVID, formally known as post-acute sequelae of SARS-CoV-2 infection (PASC), continues to challenge healthcare systems globally. Millions of patients experience persistent symptoms including fatigue, cognitive impairment, pain, and sleep disturbances t

By Yoon Hang "John" Kim, MD, MPH About the Author:  Dr. Yoon Hang "John" Kim is a board-certified integrative medicine physician with over 20 years of clinical experience. He completed his integrative medicine fellowship at the University of Arizona under Dr. Andrew Weil and holds certifications in preventive medicine, medical acupuncture, and integrative/holistic medicine. Dr. Kim is a recognized expert in low-dose naltrexone (LDN) therapy, having authored three books and mo

Mold-related illness—often called Chronic Inflammatory Response Syndrome (CIRS)—is one of the most misunderstood conditions in modern medicine. It arises from exposure to biotoxins in water-damaged buildings and triggers a cascade of immune dysregulation that can affect virtually every system in the body. Patients often present with an overwhelming constellation of symptoms: crushing fatigue, cognitive impairment (the dreaded "brain fog"), chronic pain, and a profound sense t

Edited by Yoon Hang Kim MD MPH About Dr. Kim Dr. Yoon Hang "John" Kim is a board-certified integrative medicine physician with over 20 years of clinical experience. He completed his integrative medicine fellowship at the University of Arizona under Dr. Andrew Weil and holds certifications in preventive medicine, medical acupuncture, and integrative/holistic medicine. Through his telemedicine practice, Dr. Kim specializes in utilizing LDN or Low Dose Naltrexone for treating au

A Practical Approach to Treating SIBO By Yoon Hang Kim, MD About Dr. Kim Dr. Yoon Hang "John" Kim is a board-certified integrative medicine physician with over 20 years of clinical experience. He completed his integrative medicine fellowship at the University of Arizona under Dr. Andrew Weil and holds certifications in preventive medicine, medical acupuncture, and integrative/holistic medicine. Through his telemedicine practice, Dr. Kim specializes in utilizing LDN or Low Dos

by Yoon Hang Kim MD About Dr. Kim Dr. Yoon Hang "John" Kim is a board-certified integrative medicine physician with over 20 years of clinical experience. He completed his integrative medicine fellowship at the University of Arizona under Dr. Andrew Weil and holds certifications in preventive medicine, medical acupuncture, and integrative/holistic medicine. Through his telemedicine practice, Dr. Kim specializes in utilizing LDN or Low Dose Naltrexone for treating autoimmune co

I've been treating SIBO for over two decades now, and for most of that time, the standard two-gas breath test served us reasonably well. We'd measure hydrogen and methane, apply the consensus thresholds, and treat accordingly. But something always nagged at me: there were patients who had all the classic symptoms—the bloating, the unpredictable bowels, the fatigue—yet their breath tests came back essentially flat.

Cancer treatment has evolved well beyond chemotherapy and radiation. Integrative oncology—an approach that addresses both disease progression and quality of life—has become an increasingly important part of comprehensive cancer care. Among the most promising low-toxicity interventions is low-dose naltrexone (LDN). Originally developed as an opioid antagonist at higher doses, LDN shows remarkable immunomodulatory and anti-proliferative properties when given at doses between 1.

How to Diagnose SIBO: A Guide to Current Diagnostic Methods By Yoon Hang Kim MD MPH About Dr. Kim Dr. Yoon Hang "John" Kim is a board-certified integrative medicine physician with over 20 years of clinical experience. He completed his integrative medicine fellowship at the University of Arizona under Dr. Andrew Weil and holds certifications in preventive medicine, medical acupuncture, and integrative/holistic medicine. Through his telemedicine practice, Dr. Kim specializes in

Small intestinal bacterial overgrowth (SIBO) remains one of the more frustrating conditions in gastroenterology—not because we can't treat it, but because it keeps coming back. Standard antibiotic therapy works, but relapse rates are discouragingly high. That's why many of us in integrative medicine and functional medicine have turned to low-dose naltrexone (LDN) as an adjunctive therapy. This article examines the science behind LDN, the clinical evidence supporting its use i

Low Dose Naltrexone (LDN) for Lyme Disease: An Integrative Medicine Perspective Yoon Hang "John" Kim, MD, MPH Board-Certified Integrative Medicine Physician Direct Integrative Care Keywords: Low Dose Naltrexone, LDN, Lyme Disease, Post-Treatment Lyme Disease Syndrome, Integrative Medicine, Functional Medicine, Chronic Inflammation, Immunomodulation Low Dose Naltrexone (LDN) for Lyme Disease: About the Author Dr. Yoon Hang "John" Kim, residential fellowship trained in integrat

Multiple sclerosis (MS) remains one of the most challenging autoimmune disorders affecting the central nervous system, characterized by chronic inflammation, progressive demyelination, and cumulative neurological disability. For the estimated 2.8 million people living with MS worldwide, the journey involves navigating complex treatment decisions, managing unpredictable symptoms, and maintaining quality of life despite disease progression (Walton et al., 2020). While conventio

Probiotics have become a cornerstone of integrative medicine and functional medicine practice, offering evidence-based options for gastrointestinal conditions and broader health optimization. This clinical review synthesizes current evidence from randomized controlled trials, systematic reviews, and meta-analyses examining probiotic efficacy for antibiotic-associated diarrhea, irritable bowel syndrome, ulcerative colitis, and pouchitis. The integrative medicine approach empha

Understanding Menopause Supplements: Integrative Medicine Functional Medicine Phytoestrogens and Plant-Based Therapies Combination Botanical Formulations When Supplements May Be Appropriate Individuals may reasonably consider supplement use when menopausal symptoms affect daily life but they cannot, do not wish to, or are not yet candidates for systemic hormone therapy—for example, during early symptom evaluation, with mild symptom burden, or when certain risk profiles make

By Yoon Hang "John" Kim, MD, MPH About Dr. Kim Dr. Yoon Hang "John" Kim is a board-certified integrative medicine physician with over 20 years of clinical experience. He completed his integrative medicine fellowship at the University of Arizona under Dr. Andrew Weil and holds certifications in preventive medicine, medical acupuncture, and integrative/holistic medicine. Through his telemedicine practice, Dr. Kim specializes in utilizing LDN or Low Dose Naltrexone for treating

Edited by Yoon Hang Kim MD MPH About Dr. Kim Dr. Yoon Hang "John" Kim is a board-certified integrative medicine physician with over 20 years of clinical experience. He completed his integrative medicine fellowship at the University of Arizona under Dr. Andrew Weil and holds certifications in preventive medicine, medical acupuncture, and integrative/holistic medicine. Through his telemedicine practice, Dr. Kim specializes in autoimmune conditions, chronic pain, integrative onc

Evidence-Based Review: Supplements for Female Sexual Function A Practical Guide for Integrative and Functional Medicine Perspective Edited by Yoon Hang Kim MD MPH About Dr. Kim Dr. Yoon Hang "John" Kim is a board-certified integrative medicine physician with over 20 years of clinical experience. He completed his integrative medicine fellowship at the University of Arizona under Dr. Andrew Weil and holds certifications in preventive medicine, medical acupuncture, and integrati

Yoon Hang Kim MD Complex Regional Pain Syndrome (CRPS) remains one of the most challenging chronic pain conditions we encounter. Patients typically present with severe, disproportionate pain following injury or surgery, often accompanied by sensory disturbances, temperature and color changes, swelling, and motor dysfunction. The underlying pathophysiology involves both peripheral and central sensitization, with sympathetic nervous system dysregulation and neuroinflammation pl

Using LDN to Treat Neuropathy Edited by Yoon Hang Kim MD MPH About Dr. Kim Dr. Yoon Hang “John” Kim is a fellowship-trained integrative and functional medicine physician with over 20 years of experience. He completed a residential fellowship in integrative medicine at the University of Arizona under Dr. Andrew Weil and is a 2024 Functional Medicine for All scholarship recipient from the Institute for Functional Medicine. After serving as Chief Wellness Officer at a rural comm

Integrative Functional Medicine Approach to Enhancing Blood Flow Healthy blood flow is a foundation of systemic wellness. For practitioners of integrative medicine  and functional medicine , addressing poor circulation isn’t just about managing symptoms—it is about optimizing the body’s fundamental delivery system. When blood flow  is compromised, nutrient delivery and waste removal suffer, impacting everything from energy levels to tissue repair. Optimizing blood flow throug