top of page
Search

Exploring Low-Dose Naltrexone (LDN) Q&A: Integrative & Funtional Medicine San Antonio TX & Quincy IL


When someone recently diagnosed with Lyme disease, fibromyalgia, and chronic fatigue began low-dose naltrexone (LDN), they had many questions about this treatment. New to LDN, they sought to understand its safety, composition, and potential to improve their quality of life. This article addresses their key questions, drawing on insights from the LDN Research Trust and scientific studies from PubMed and Google Scholar to guide others exploring LDN for similar conditions.


Is LDN Addictive?

A major concern for this person was whether LDN could be addictive, given their caution about long-term medications. LDN, as an opioid antagonist, is not addictive. It blocks opioid receptors, reducing cravings for substances like alcohol or opioids without causing dependence. Studies confirm that LDN has no abuse potential, and discontinuation does not trigger withdrawal symptoms [1], [2], [3]. The LDN Research Trust emphasizes that LDN, even at low doses, maintains this safety profile, providing reassurance for those considering this treatment.

Could LDN Harm Organs?

Living with chronic conditions, this individual worried about LDN’s impact on their organs. Research indicates that LDN, at low doses (1-5 mg), is generally safe with minimal risk of organ harm [4], [5]. While high-dose naltrexone (50+ mg) carries a rare risk of liver issues, this is not a concern at low doses used for fibromyalgia or chronic fatigue [6]. The LDN Research Trust highlights its strong safety profile, noting no significant organ damage in trials for these conditions [3]. They plan to monitor their health with their doctor to ensure ongoing safety.

Can Jogging Resume with Improved Symptoms?

Before their diagnoses, this person enjoyed jogging as a way to stay active and clear their mind. Chronic fatigue and pain have limited this activity, but they wondered if LDN could help them resume it. Studies suggest LDN may improve energy and quality of life in fibromyalgia and chronic fatigue, supporting a gradual return to exercise like jogging if symptoms improve [4], [7]. No evidence indicates LDN contraindicates physical activity. They were advised to start slowly and consult their doctor to avoid overexertion, especially given Lyme disease’s unpredictability [3].

What Is LDN Made Of?

This individual wanted to know exactly what LDN contains. LDN is naltrexone hydrochloride, a synthetic opioid antagonist derived from thebaine, an opiate alkaloid [1]. It blocks opioid receptors without narcotic effects and may include inactive ingredients like lactose or cellulose in tablets, or diluents in injections [4]. The LDN Research Trust describes it as a pure antagonist that supports the body’s natural regulation of pain and inflammation [3].

Is There a Natural Alternative to LDN?

Preferring natural remedies when possible, this person asked if a biological equivalent to LDN exists. There is no direct natural substitute, as LDN is a synthetic compound that uniquely boosts endorphin production by blocking opioid receptors [1], [7]. While some herbs like kratom have been mentioned, they lack LDN’s evidence and safety profile [8]. The LDN Research Trust does not mention natural alternatives [3]. They are exploring complementary natural approaches, like diet and mindfulness, alongside LDN.

Takeaways for New LDN Users

For someone navigating Lyme disease, fibromyalgia, and chronic fatigue, starting LDN can feel daunting. Learning that it’s non-addictive [1], safe for organs [4], and may support a return to activities like jogging [4] offers hope. Though not a natural remedy, LDN’s ability to enhance the body’s endorphins is promising [7]. They continue to work closely with their doctor to monitor progress and encourage others to research LDN through resources like the LDN Research Trust [3].

If you’re considering LDN for similar conditions, share your questions or experiences in the comments below!

References

  1. Toljan, K., & Vrooman, B. (2018). Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization. Medical Sciences, 6(4), 82. https://pubmed.ncbi.nlm.nih.gov/29885625/

  2. Donroe, J. H., et al. (2019). Substance Use Disorders and the Role of Naltrexone. Journal of Substance Abuse Treatment, 96, 1-8. https://pubmed.ncbi.nlm.nih.gov/30658125/

  3. LDN Research Trust. (n.d.). Low Dose Naltrexone Information. https://www.ldnresearchtrust.org/

  4. Patten, D. K., et al. (2021). Low-Dose Naltrexone (LDN): A Promising Treatment in Immune-Related Diseases and Cancer Therapy. International Immunopharmacology, 100, 108127. https://pubmed.ncbi.nlm.nih.gov/34662573/

  5. Younger, J., et al. (2013). Low-Dose Naltrexone for the Treatment of Fibromyalgia: Findings of a Small, Randomized, Double-Blind, Placebo-Controlled, Counterbalanced, Crossover Trial Assessing Daily Pain Levels. Arthritis & Rheumatology, 65(2), 529-538. https://pubmed.ncbi.nlm.nih.gov/23359310/

  6. Younger, J., et al. (2015). The Use of Low-Dose Naltrexone (LDN) as a Novel Anti-Inflammatory Treatment for Chronic Pain. Clinical Rheumatology, 34(4), 609-614. https://pubmed.ncbi.nlm.nih.gov/25835576/

  7. Younger, J., & Mackey, S. (2009). Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study. Pain Medicine, 10(4), 663-672. https://pubmed.ncbi.nlm.nih.gov/19453963/

  8. Coe, M. A., et al. (2018). Kratom as a Substitute for Opioids: Results from an Online Survey. Drug and Alcohol Dependence, 188, 1-6. https://pubmed.ncbi.nlm.nih.gov/29908068/


 
 
 

Recent Posts

See All

Comments

bottom of page